What's the most likely diagnosis?

• 42 year-old female with chest pain

1. Pneumothorax
2. Cleidocranial dysostosis
3. Right middle lobe pneumonia
4. Thyroid goiter
5. Congestive heart failure

Additional Image-abdominal radiograph

 

Additional Image

 

Abdominal and pelvic radiograph

Answer:

 

2. Cleidocranial dysostosis

 

 

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Pancoast Tumor

General Considerations

• Rare, congenital hereditary dysostosis resulting in delayed or failed ossification of midline structures
  • Especially membranous bones, but enchondral bones are also affected
• Therefore, skull and clavicles are mostly affected
• Autosomal dominant with strong familial tendencies
• Males and females have same chance of being affected
• Gene for this disorder has been found on Chromosome 6
• May also occur as a sporadic mutation
• Major changes are in the skull, clavicles and pelvis 

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